Plate?height model of ion mobility?mass spectrometry: Part 2—Peak?to?peak resolution and peak capacity

In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing plate-height model [1]. On basis of these findings, present theoretical study extends by exploring peak-to-peak resolution peak capacity mobility separations. The first part provides critical overview chromatography-influenced equations, including refinement existing formulae. Furthermore, exact equations for based on principles. Upon implementing simple modifications, formulae could be readily extended to traveling wave separations cases when is coupled mass spectrometry. second focuses capacity. well-known assumptions constant number width form approximate solutions. To overcome their limitations, an equation derived This solution rooted suitable physical broadening, accounting finite injection pulse subsequent diffusional spreading. By borrowing concepts from toolbox chromatography, believe that will help integrating into unified language separation science.